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Colloquium - Light-based Theranostics Using Optical Particles Derived from Erythrocytes

Date: 
Monday, December 4, 2017 - 14:00
Location: 
KHE 225

Presenter: Bahman Anvari
Department of Bioengineering
University of California, Riverside

Abstract:

Our laboratory has engineered constructs derived from erythrocytes, which can be doped with optical agents including near infrared (NIR) dyes such as the FDA-approved, indocyanine green (ICG). We refer to these constructs as NIR erythrocyte-derived transducers (NETs). A key feature of NETs is that their diameters can be tuned from micron to nano scale using appropriate mechanical manipulation of the erythrocytes. In this seminar, I will present the results of some of our ongoing activities including the material characteristics of NETs, and their utility as photo-theranostic agents for fluorescence imaging and photo-destruction of structures such as tumors and blood vessels using in vitro and animal models. As potentially biocompatible constructs, NETs may provide a versatile platform for various clinical applications ranging from image-guided removal of tumors to vascular imaging and phototherapy.

Speaker Bio:

Bahman Anvari received his B.A. in Biophysics from University of California, Berkeley, and Ph.D. in Bioengineering from Texas A&M University. He was a Postdoctoral Researcher at the Beckman Laser Institute (BLI), and later a Research Assistant Professor of Engineering at Harvey Mudd College (HMC). He joined the Bioengineering Department at Rice University in 1998 as an Assistant Professor, and became an Associate Professor in 2003. In 2006, Dr. Anvari joined the newly established Department of Bioengineering at University of California, Riverside (UCR) as a Professor. Dr. Anvari’s scientific interests are in the development and application of optical technologies for imaging and therapeutic purposes. He has authored over 300 scientific articles. He has served as an Associate Editor for the Annals of Biomedical Engineering, and is an Editorial Board Member of Journal of Biomedical Optics. Dr. Anvari is a Fellow of the American Association for the Advancement of Science (AAAS), American Institute for Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), and The International Society for Optics and Photonics (SPIE).